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Retrieved on 4 July 2007.

This, along with differences in marketing and changing consumer preferences, has caused aspartame to lose market share to sucralose.

Following initial safety testing, there was debate as to whether these tests had indicated that aspartame may cause cancer in rats; as a result, the U.

Some critics believe it to be used in all foods.

On May 25, 2000 Monsanto sold it to J.

At room temperature, it is most stable at pH 4.

He discovered its sweet taste serendipitously when he licked his finger, which had accidentally become contaminated with aspartame.

References^ Merck Index, 11th Edition, 861.

// MarketingThis sweetener is marketed under a number of trademark names, including Equal, NutraSweet, and Canderel, and is an ingredient of approximately 6,000 consumer foods and beverages sold worldwide.

Searle's Chief Operating Officer, Donald Rumsfeld, reapplied for FDA certification immediately after U.

In 1983, the FDA further approved aspartame for use in dry goods.

In 1980, the FDA convened a Public Board of Inquiry (PBOI) consisting of independent advisors charged with examining the purported relationship between aspartame and brain cancer.

Food and Drug Administration (FDA) did not approve its use as a food additive in the United States for many years.

In 1985, Monsanto bought G.

Since then the company has faced hot competition in market for aspartame from other manufacturers, including Ajinomoto, Merisant and the Holland Sweetener Company, which stopped making the chemical in late 2006 because "global aspartame markets are facing structural oversupply, which has caused worldwide strong price erosion over the last five years" making the business "persistently unprofitableā€.

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To this day, the health effects of aspartame have been under intensive study.

The stability of aspartame under heating can be improved to some extent by encasing it in fats or in maltodextrin.

Discovery and approvalAspartame was discovered...

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